A brain tumour isn't usually the subject of a comedy show but Britney, written and performed by comedy duo Charly Clive and Ellen Robertson, is just that. It's “the true story of what happens to two best friends when one of them [Clive] gets a brain tumour” – the size of a golf ball, her father helpfully pointed out.

Tommy Tiernan is something of an institution in his native Ireland, as a stand-up comic, newspaper columnist, sometime chat show host and full-time controversialist. Now his appearance as Da Gerry in Channel 4's Derry Girls has brought him to a wider audience – both geographically and generationally – and deservedly so.

Angela Barnes is one of life’s pessimists, she tells us at the top of the hour, but she’s trying not to be so world-weary, and to turn negatives into positives. And, while there’s so much awfulness going on around us, why not try to lighten the mood a little?

Most people in the UK know American actor and stand-up Aziz Ansari from Parks and Recreation, where he played the sarcastic and underachieving local government official Tom Haverford. Comedy fans will also know him as a successful club comic on both US coasts, and from his Netflix specials.

Ed Gamble starts the hour by telling us why his latest show is called Blizzard; he and a bunch of comic friends we stranded in New York by bad weather and it made the news - yet, strangely, the headline wasn’t a play on his name - a gift for hacks - but on the monicker of one of his mates. Cue faux outrage.

Have you ever felt the hot shame of saying or doing the wrong thing? Not just embarrassment – that's for amateurs, says Lou Sanders in her wonderfully honest and revealing show Shame Pig, in which she essays some of her life's red-faced moments. Embarrassment is fleeting and lends itself to a good anecdote (or a fine joke in a stand-up set), she says, while shame is a much more corrosive emotion, and one that young women in particular burden themselves with unnecessarily.

Sheeps, the sketch comedy threesome, had never really gone away but when they performed Live and Loud Selfie Sex Harry Potter at the Edinburgh Fringe last year after a four-year absence, it was called a comeback. More a welcome reunion, as its members – Liam Williams, Daran Johnson and Alastair Roberts – had been busy doing solo projects.

The show, which they have brought to the Soho Theatre for a short run, is in the same vein as their previous work – original and intelligent sketch comedy with a touch of edginess and the surreal.

The first line of this show is “I'm the guy who you meet right after you come out of a long-term relationship.” On the night I see The Guy Who..., Adam Riches has three tries with it before he meets his target, a woman who has been dumped by a long-standing boyfriend.

Lost Voice Guy – aka Lee Ridley – won Britain’s Got Talent last year. He's a unique talent in that his cerebral palsy means he is unable to speak, and so he delivers his comedy through a synthesizer controlled via his iPad.

Daniel Sloss's latest show is called X, to denote his 10th show. The Scottish comic started in comedy as a teenager in 2009 when a lot of his material was knob and wank gags, but in recent years his work has had a progressively edgier feel, including shows that delved into his sister's death from cerebral palsy and the childhood grooming from which he had a lucky escape.